Journal Club

Title: Neural engineering: the process, applications, and its role in the future of medicine

Abstract:

Objective. Recent advances in neural engineering have restored mobility to people with paralysis, relieved symptoms of movement disorders, reduced chronic pain, restored the sense of hearing, and provided sensory perception to individuals with sensory deficits.

Approach. This progress was enabled by the team-based, interdisciplinary approaches used by neural engineers. Neural engineers have advanced clinical frontiers by leveraging tools and discoveries in quantitative and biological sciences and through collaborations between engineering, science, and medicine. The movement toward bioelectronic medicines, where neuromodulation aims to supplement or replace pharmaceuticals to treat chronic medical conditions such as high blood pressure, diabetes and psychiatric disorders is a prime example of a new frontier made possible by neural engineering. Although one of the major goals in neural engineering is to develop technology for clinical applications, this technology may also offer unique opportunities to gain insight into how biological systems operate.

Main results. Despite significant technological progress, a number of ethical and strategic questions remain unexplored. Addressing these questions will accelerate technology development to address unmet needs. The future of these devices extends far beyond treatment of neurological impairments, including potential human augmentation applications. Our task, as neural engineers, is to push technology forward at the intersection of disciplines, while responsibly considering the readiness to transition this technology outside of the laboratory to consumer products.

Significance. This article aims to highlight the current state of the neural engineering field, its links with other engineering and science disciplines, and the challenges and opportunities ahead. The goal of this article is to foster new ideas for innovative applications in neurotechnology.

Slides from the meeting can be found here.

Title: An Integrated Brain-Machine Interface Platform With Thousands of Channels

Abstract:

Brain-machine interfaces hold promise for the restoration of sensory and motor function and the treatment of neurological disorders, but clinical brain-machine interfaces have not yet been widely adopted, in part, because modest channel counts have limited their potential. In this white paper, we describe Neuralink’s first steps toward a scalable high-bandwidth brain-machine interface system. We have built arrays of small and flexible electrode “threads,” with as many as 3072 electrodes per array distributed across 96 threads. We have also built a neurosurgical robot capable of inserting six threads (192 electrodes) per minute. Each thread can be individually inserted into the brain with micron precision for avoidance of surface vasculature and targeting specific brain regions. The electrode array is packaged into a small implantable device that contains custom chips for low-power on-board amplification and digitization: The package for 3072 channels occupies less than 23×18.5×2 mm3. A single USB-C cable provides full-bandwidth data streaming from the device, recording from all channels simultaneously. This system has achieved a spiking yield of up to 70% in chronically implanted electrodes. Neuralink’s approach to brain-machine interface has unprecedented packaging density and scalability in a clinically relevant package.

Slides from the meeting can be found here.

Title: A soft neuroprosthetic hand providing simultaneous myoelectric control and tactile feedback

Abstract:

Neuroprosthetic hands are typically heavy (over 400 g) and expensive (more than US$10,000), and lack the compliance and tactile feedback of human hands. Here, we report the design, fabrication and performance of a soft, low-cost and lightweight (292 g) neuroprosthetic hand that provides simultaneous myoelectric control and tactile feedback. The neuroprosthesis has six active degrees of freedom under pneumatic actuation, can be controlled through the input from four electromyography sensors that measure surface signals from residual forearm muscles, and integrates five elastomeric capacitive sensors on the fingertips to measure touch pressure so as to enable tactile feedback by eliciting electrical stimulation on the skin of the residual limb. In a set of standardized tests performed by two individuals with transradial amputations, we show that the soft neuroprosthetic hand outperforms a conventional rigid neuroprosthetic hand in speed and dexterity. We also show that one individual with a transradial amputation wearing the soft neuroprosthetic hand can regain primitive touch sensation and real-time closed-loop control.

Slides from the meeting can be found here.

Title: Potential Impacts of Smart Homes on Human Behavior: A Reinforcement Learning Approach

Abstract:

We aim to investigate the potential impacts of smart homes on human behavior. To this end, we simulate a series of human models capable of performing various activities inside a reinforcement learning-based smart home. We then investigate the possibility of human behavior being altered as a result of the smart home and the human model adapting to one-another. We design a semi-Markov decision process human task interleaving model based on hierarchical reinforcement learning that learns to make decisions to either pursue or leave an activity. We then integrate our human model in the smart home which is based on Q-learning. We show that a smart home trained on a generic human model is able to anticipate and learn the thermal preferences of human models with intrinsic rewards similar to the generic model. The hierarchical human model learns to complete each activity and set optimal thermal settings for maximum comfort. With the smart home, the number of time steps required to change the thermal settings are reduced for the human models. Interestingly, we observe that small variations in the human model reward structures can lead to the opposite behavior in the form of unexpected switching between activities which signals changes in human behavior due to the presence of the smart home.

Slides from the meeting will be uploaded after the meeting.